James B Young Selected Research

Messenger RNA (mRNA)

9/2005	Peritransplant ischemic injury is associated with up-regulation of stromal cell-derived factor-1.
8/2005	Systemic activation of integrin alphaVbeta3 in donors with spontaneous intracerebral hemorrhage is associated with subsequent development of vasculopathy in the heart transplant recipient.
7/2004	Systemic up-regulation of angiotensin II type 1 receptor in cardiac donors with spontaneous intracerebral hemorrhage.
10/2003	Donor spontaneous intracerebral hemorrhage is associated with systemic activation of matrix metalloproteinase-2 and matrix metalloproteinase-9 and subsequent development of coronary vasculopathy in the heart transplant recipient.

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James B Young Research Topics

Disease

98	Heart Failure 04/2022 - 03/2002
10	Systolic Heart Failure 04/2022 - 12/2003
8	Left Ventricular Dysfunction 03/2016 - 03/2002
6	Anemia 04/2022 - 02/2006
6	Diabetes Mellitus 01/2018 - 01/2004
5	Weight Loss (Weight Reduction) 01/2019 - 02/2005
4	Cardiomyopathies (Cardiomyopathy) 12/2020 - 10/2003
4	COVID-19 10/2020 - 01/2020
4	Hypertension (High Blood Pressure) 01/2020 - 02/2004
4	Infections 01/2018 - 11/2005
4	Myocardial Infarction 01/2018 - 07/2002
4	Hypotension (Low Blood Pressure) 09/2015 - 07/2003
4	Atrial Fibrillation 07/2006 - 12/2003
4	Fibrosis (Cirrhosis) 11/2005 - 03/2002
3	Thrombosis (Thrombus) 01/2020 - 07/2014
3	Dyspnea (Shortness of Breath) 01/2020 - 07/2003
3	Stroke (Strokes) 01/2018 - 03/2013
3	Hemorrhage 01/2018 - 02/2004
3	Diastolic Heart Failure 01/2009 - 08/2006
3	Mitral Valve Insufficiency (Mitral Regurgitation) 05/2008 - 02/2004
3	Necrosis 08/2007 - 09/2002
3	Ventricular Remodeling 04/2006 - 03/2002
3	Ischemia 11/2005 - 04/2002
3	Cerebral Hemorrhage 08/2005 - 10/2003
3	Wounds and Injuries (Trauma) 08/2005 - 10/2003
3	Coronary Artery Disease (Coronary Atherosclerosis) 05/2005 - 03/2004
2	Lung Diseases (Lung Disease) 01/2020 - 10/2008
2	Chronic Renal Insufficiency 01/2018 - 11/2015
2	Unstable Angina 01/2018 - 08/2006
2	Neoplasms (Cancer) 01/2014 - 09/2012
2	Cardiogenic Shock 09/2012 - 02/2003
2	Coronary Disease (Coronary Heart Disease) 11/2011 - 07/2008
2	Viremia 08/2010 - 03/2004
2	Bundle-Branch Block (Fascicular Block) 07/2008 - 12/2003
2	Hyperkalemia 11/2007 - 10/2004
2	Weight Gain 04/2003 - 04/2002
1	Diarrhea 01/2020
1	Morbid Obesity 01/2019
1	Hemolysis 01/2018
1	Surgical Wound Infection 01/2018
1	Venous Thromboembolism 01/2018
1	Acute Kidney Injury (Acute Renal Failure) 01/2018
1	Inflammation (Inflammations) 12/2017
1	Sleepiness 12/2017
1	Sleep Apnea Syndromes (Sleep Apnea) 12/2017
1	Disorders of Excessive Somnolence (Hypersomnia) 12/2017
1	Obesity 03/2016

Drug/Important Bio-Agent (IBA)

12	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 10/2020 - 10/2004
12	CreatinineIBA 10/2016 - 09/2002
12	candesartanIBA 06/2008 - 10/2003
11	Angiotensin Receptor AntagonistsIBA 10/2020 - 10/2004
9	Pharmaceutical PreparationsIBA 10/2020 - 09/2002
8	Darbepoetin alfa (Aranesp)FDA Link 04/2022 - 08/2009
8	Brain Natriuretic Peptide (Natrecor)FDA Link 09/2009 - 09/2002
7	Digoxin (Digitek)FDA LinkGeneric 01/2009 - 03/2002
6	Hemoglobins (Hemoglobin)IBA 01/2018 - 02/2006
4	DiureticsIBA 09/2009 - 08/2006
4	Messenger RNA (mRNA)IBA 09/2005 - 10/2003
3	Vasodilator Agents (Vasodilators)IBA 09/2015 - 01/2007
2	CytokinesIBA 04/2022 - 04/2007
2	Biomarkers (Surrogate Marker)IBA 01/2018 - 12/2017
2	Hydralazine (Apresoline)FDA LinkGeneric 09/2015 - 04/2009
2	Isosorbide Dinitrate (Isordil)FDA LinkGeneric 09/2015 - 04/2009
2	NitrogenIBA 07/2014 - 09/2012
2	Urea (Carbamide)FDA LinkGeneric 07/2014 - 09/2012
2	PotassiumIBA 05/2010 - 11/2007
2	SodiumIBA 10/2008 - 07/2008
2	Natriuretic PeptidesIBA 02/2008 - 07/2006
2	Indicators and Reagents (Reagents)IBA 11/2007 - 05/2005
2	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA 05/2006 - 10/2004
2	Integrin alphaVbeta3IBA 08/2005 - 02/2002
2	Angiotensin IIIBA 05/2004 - 03/2004
2	thiazole-4-carboxamide adenine dinucleotide (TCAD)IBA 05/2004 - 03/2004
2	Matrix Metalloproteinases (MMPs)IBA 10/2003 - 04/2002
1	Ferritins (Ferritin)IBA 04/2022
1	IronIBA 04/2022
1	Growth Differentiation Factor 15IBA 04/2022
1	Amyloid (Amyloid Fibrils)IBA 12/2020
1	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 01/2020
1	HematinicsIBA 01/2018
1	pro-brain natriuretic peptide (1-76)IBA 01/2018
1	omega-Chloroacetophenone (Mace)IBA 01/2018
1	Clostridium perfringens epsilon-toxinIBA 04/2017
1	Tolvaptan FDA Link 01/2017

Therapy/Procedure

41	Therapeutics 01/2020 - 03/2002
16	Heart Transplantation (Grafting, Heart) 01/2019 - 03/2002
11	Heart-Assist Devices 01/2020 - 08/2002
9	Transplantation 01/2016 - 04/2002
8	Cardiac Resynchronization Therapy 01/2022 - 05/2003
8	Patient Readmission 01/2018 - 01/2007
5	Length of Stay 01/2018 - 07/2004
4	Drug Therapy (Chemotherapy) 01/2014 - 01/2004
3	Bariatric Surgery 01/2019 - 03/2016
2	Operative Surgical Procedures 12/2012 - 03/2002
2	Catheters 09/2009 - 08/2008
2	Implantable Defibrillators (Implantable Cardioverter-Defibrillator) 11/2004 - 05/2003
1	Artificial Respiration (Mechanical Ventilation) 01/2020
1	Patient Transfer (Patient Dumping) 01/2020
1	Gastrectomy 01/2019
1	Operative Time 01/2018